Journal of Medicinal Chemistry p. 117 - 122,118, 120 (1976)
Update date:2022-08-11
Topics:
Ahmed
Hanna
Grund
The syntheses of trans and cis 1 benzyl 3 dimethylamino 6 phenylpiperidine (1 and 2) are described. Compounds 1 and 2 were found to be inhibitors of histamine, acetylcholine, and barium chloride induced contractions of the isolated guinea pig ileum. Compounds 1 and 2 do not exhibit appreciable stereoselectivity in their ability to inhibit smooth muscle contractions. The cis compound 2 is a more effective inhibitor of histamine N methyltransferase than the trans isomer 1.
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