2847-91-8Relevant academic research and scientific papers
Conformationally restricted analogs of histamine H1 receptor antagonists: trans and cis 1 benzyl 3 dimethylamino 6 phenylpiperidine
Ahmed,Hanna,Grund
, p. 117 - 122,118, 120 (1976)
The syntheses of trans and cis 1 benzyl 3 dimethylamino 6 phenylpiperidine (1 and 2) are described. Compounds 1 and 2 were found to be inhibitors of histamine, acetylcholine, and barium chloride induced contractions of the isolated guinea pig ileum. Compounds 1 and 2 do not exhibit appreciable stereoselectivity in their ability to inhibit smooth muscle contractions. The cis compound 2 is a more effective inhibitor of histamine N methyltransferase than the trans isomer 1.
Double diastereoselectivite de la cycloaddition dipolaire-1,3 d'ylures d'azomethine cycliques substitues
Lakhlifi, Tahar,Sedqui, Ahmed,Fathi, Toufik,Laude, Bernard,Robert, Jean-Francois
, p. 1417 - 1423 (2007/10/02)
Seven derivatives of methyl 5-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylates 1 were synthesized.These compounds are precursors of pentagonal cyclic azomethine ylides, the two sides of which are diastereotopic.The 1,3-dipolar species react with N-methyl and
