Kinetics of Neutral Hydrolysis of Two 1-Acyl-1,2,4-triazoles in Binary Aqueous Mixtures: A Critique of the Evans and Polanyi Proposals Concerning Isochoric Activation Parameters

Article abstract of DOI:10.1021/ja00307a033

Kinetic data are reported for hydrolysis of two 1-acyl-1,2,4-triazoles in water and two isodielectric mixtures which belong to different classes of aqueous mixtures.Trends in isothermal and isobaric activation parameters are examined in light of both solute-solvent interactions.Comments by Evans and Polanyi concerning an isochoric constraint are considered.Attention is drawn to the difficulties of satisfying the original criteria and to the possibility of using the internal pressure of the solvent as a way of satisfying in part the requirements of the Evans-Polanyi formalism.