Bioorganic and Medicinal Chemistry Letters p. 1151 - 1154 (2000)
Update date:2022-08-05
Topics:
Wang, Wuyi
Preville, Patrice
Morin, Nicolas
Mounir, Samir
Cai, Weizhong
Siddiqui, M. Arshad
An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure-activity relationship study on a phenazine hit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency. (C) 2000 Elsevier Science Ltd. All rights reserved.
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