Chemistry - A European Journal p. 16063 - 16067 (2019)
Update date:2022-08-11
Topics:
Sushmita
Aggarwal, Trapti
Shibata, Norio
Verma, Akhilesh K.
A metal-free, versatile triple-bond directed approach for the decarbonylative C?H amination of ortho-alkynyl quinoline/pyridine aldehydes using N-fluorobenzenesulfonimide as nitrogen source under mild reaction conditions has been described. The designed reaction strategy was triggered by trapping of fluorine by base with subsequent attack of bis(phenylsulfonyl)-λ2-azane on the carbonyl carbon of a heterocycle, which was gradually converted into the corresponding amine through a Curtius type rearrangement. This protocol provides a one-step approach for the conversion of aldehydes into amines in good yields. The synthesized amines were successfully transformed into biologically important pyrroloquinolines/pyridines.
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Doi:10.1055/s-0034-1380538
(2015)Doi:10.1016/j.catcom.2014.09.036
(2015)Doi:10.1039/jr9370001559
(1937)Doi:10.1016/j.tetlet.2004.09.005
(2004)Doi:10.1055/s-2006-948205
(2006)Doi:10.1039/c4ra16316h
(2015)