A simple synthesis of acetyl and propionyl cyclododecanes

Article abstract of DOI:10.1007/BF00697104

1-Formyl-4,8-cyclododecadiene, obtained by hydroformylation of 1,5,9-cyclodecatriene, reacts with MeMgHal or EtMgHal to give 1-(1'-hydroxyethyl)- or 1-(1'-hydroxypropyl)-4,8-cyclodecadiene, respectively.The hydrogenation of their double bonds and subsequent oxidation of the resulting alcohols afford, in high yields, acetyl- or propionylcyclododecane, respectively.