Tetrahedron Letters p. 4009 - 4012 (1995)
Update date:2022-08-29
Topics:
Buonora, Paul T.
The influence of the addition of Lewis acid (zinc nitrate-hexahydrate) and Lewis base (N,N-dimethylaminoethanol) on the aqueous Claisen-Schmidt reaction was investigated. The results demonstrate the preferential activation of the aldol addition reaction by the zinc ion under either specific or general base conditions. A protocol has been developed which selectively produces aldol addition products under aqueous conditions.
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