One-Pot Synthesis of Substituted Homoallylic Alcohols (3-Alkenols) and 1,1-Dideuterio-3-alkenols

Article abstract of DOI:10.1055/s-1986-31735

The reaction of the lithium enolate of ethyl acetate with various α-chlorocarbonyl compounds followed by in situ reduction with lithium aluminium hydride or deuteride and then lithiation with lithium powder leads, after hydrolysis, to homoallylic alcohols in a regioselective manner.