Chelation, activation, and proximity effects in the deprotection of dithianes with ZnBr2. Applications in the polyketide field

Article abstract of DOI:10.1021/ol016037l

(Matrix presented) Double deprotection of dithiane aldol equivalents is feasible under mild conditions with ZnBr₂ and suitably placed MEM, BOM, and SEM groups which function as protecting, activating, and regiodirecting groups. The procedure is useful in natural product synthesis.