Palladium assisted alkylation-insertion reactions of chiral ene-carbamates

Article abstract of DOI:10.1055/s-1995-3960

Palladium(II) complexes of chiral ene-carbamate 2 underwent efficient, stereoselective alkylation by malonate carbanions having pendent unsaturated side chains. The resulting σ-alkylpalladium(II) complexes underwent efficient insertion of carbon monoxide to produce esters. Insertion of the pendent unsaturated groups was less efficient, and led to mixtures of insertion products with little stereoselectivity.