Synthesis of a 1,8-napththyridin-5-one derivative via an intramolecular 1,3-dipolar cycloaddition reaction

Article abstract of DOI:10.1002/jhet.5570320531

Synthesis of a 1,8-naphthyridin-5-one derivative [(5,6,7,8-tetrahydro-(3-chloro-6-hydroxymethyl-8-methyl)-1,8-naphthyri din-5-one (9)] is described starting from 2-chloronicotinic acid using an intramolecular 1,3-dipolar cycloaddition reaction as the key step.