Tetrahedron p. 1389 - 1398 (1996)
Update date:2022-08-16
Topics:
Harrowven, David C.
Poon, Hon Suen
The paper describes a convenient method for the diastereoselective synthesis of trisubstituted alkenes through the lithium amide mediated union of ketones and diethyl maleate. The reaction has been shown to proceed via a Michael initiated - condensation - elimination (MICE) sequence.
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