Synthesis of a Mexican bean beetle azamacrolide allomone via a novel lactam to lactone ring expansion

Article abstract of DOI:10.1016/0040-4039(96)00234-1

The Mexican bean beetle (Epilachna varivestis) defensive secretion azamacrolide 1 has been synthesized via the novel ring expansion of N-hydroxyethyl lactam 12, which was prepared in seven steps from cyclooctanone (6).