Loss of individual electrostatic interactions between aminoglycoside antibiotics and resistance enzymes as an effective means to overcoming bacterial drug resistance

DOI: 10.1021/ja00150a004

Source and publish data:

Journal of the American Chemical Society p. 11060 - 11069 (1995)

Update date:2022-08-16

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Authors:

Roestamadji, Juliatiek

Grapsas, Ioannis

Mobashery, Shahriar

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Article abstract of DOI:10.1021/ja00150a004

Aminoglycoside-modifying enzymes modify the structures of aminoglycoside antibiotics, rendering them ineffective, a process which confers resistance to the antibiotic. Electrostatic interactions (ion pairing and hydrogen bonding) are believed to be signif

Full text of DOI:10.1021/ja00150a004

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