TITRATION OF ORGANIC COMPOUNDS AS VERY WEAK ACIDS WITH LITHIUM SILANAMIDE

Article abstract of DOI:10.1021/ac50058a036

Numerous organic compounds, such as alcohols, acetophenones, esters, anilides, carbamates, and lactams, can be titrated as very weak acids in tetrahydrofuran.End points were determined by potentiometry and by color change of N-phenyl-p-aminoazobenzene.Relative percent errors for the determination of approximately 1.00-mmol amounts of sample generally ranged from 2 to 6percent.Examples of compounds which did not react quantitatively with the lithium silylamide reagent were benzophenone, benzylbenzoate, and N-phenylbenzylamine.