Lipase-Catalyzed Transesterification as a Practical Route to Homochiral Acyclic anti-1,2-Diols. A New Syntesis of (+)- and (-)-endo-Brevicomin.

Article abstract of DOI:10.1016/0040-4039(95)01237-C

Several anti-1,2-diols (2a-g) have been efficiently resolved by using LPS-catalyzed transesterification and the total synthesis of (+)- and (-)-endo-brevicomin (1) has been achieved starting from one (2g) of the resolved diols.