Bioorganic and Medicinal Chemistry Letters p. 1589 - 1594 (1997)
Update date:2022-08-23
Topics:
Jungheim, Louis N.
Cohen, Jeffrey D.
Johnson, Robert B.
Villarreal, Elcira C.
Wakulchik, Mark
Loncharich, Richard J.
Wang, Q. May
Homophthalimides 2a and 3a were found to be inhibitors of Rhinovirus 3C protease through a blind screening effort. SAR studies resulted in compound 3g, which exhibited improved enzyme inhibition, in addition to whole cell antiviral activity. Molecular modeling studies suggest a preferred enzyme/inhibitor interaction, and LC/MS experiments confirmed tight/covalent binding of 3g to the enzyme.
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(1972)Doi:10.1039/c39910001139
(1991)Doi:10.1016/0009-2614(95)00406-T
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