Steroidal saponins from the underground parts of Hosta longipes and their inhibitory activity on tumor promoter-induced phospholipid metabolism

DOI: 10.1248/cpb.43.1190

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1190 - 1196 (1995)

Update date:2022-08-16

Topics:

Authors:

Mimaki Mimaki

Kanmoto Kanmoto

Kuroda Kuroda

Sashida Sashida

Nishino Nishino

Satomi Satomi

Nishino Nishino

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Article abstract of DOI:10.1248/cpb.43.1190

Phytochemical study on the underground parts of Hosta longipes gave six new steroidal saponins together with a known one. The structures of the new compounds were determined by detailed analysis of their ¹H- and ¹³C-NMR spectra including two-dimensional NMR spectroscopy, acid-catalyzed hydrolysis followed by chemical correlation, and by comparison with spectral data of known compounds. The isolated saponins and their aglycones were examined for inhibitory activity on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated ³²P-incorporation into phospholipids of HeLa cells to identify new antitumor-promoter compounds.

Full text of DOI:10.1248/cpb.43.1190

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