Tetrahedron p. 4277 - 4282 (1998)
Update date:2022-08-10
Topics:
Ewers, Christian L. J.
Harre, Michael
Mohr, Joerg
Nickisch, Klaus
Tilstam, Ulf
An efficient synthesis has been developed yielding 17-epi- ethynylestradiol 2 in an overall yield of 17 %. The key derivatives 7a-c were prepared from estrone in four steps. Subsequently epoxides 7a,c were efficiently transformed into 2 via Takano's method.
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