Tetrahedron Letters p. 1877 - 1880 (1998)
Update date:2022-08-28
Topics:
Gopal, Damodaragounder
Nadkarni, Durgesh V.
Sayre, Lawrence M.
An efficient method has been developed for the synthesis of monoalkylated 1.2-diones by using steric approach control. The dihydropyrazine 2 prepared from 2,3-butanedione and 1,2-diamino-2- methylpropane is selectively deprotonated on the less hindered methyl group to give an anion which is alkylated with alkyl iodides and activated bromides. In situ hydrolysis of the alkylated dihydropyrazines gives monoalkylated diones 4 in good yield.
View More
Contact:+86-913-2223392
Address:No. 32, Xinanjing Road, Weinan City, Shaanxi Province, 714000, China
Zhejiang Haizhou Pharmaceutical Co., Ltd.
website:https://www.haizhoupharma.com/
Contact:+86-576-88221016
Address:No. 19, Donghai 5th Avenue, Yanhai Industrial Zone, Linhai, Zhejiang, China
Zhejiang Quzhou Zhengbang Organosilicon Co.,ltd.
Contact:86-570-3375195
Address:No.17 Lingqing Road technology industry,Quzhou City,Zhejiang Province,China
Zhejiang Golden-Shell Pharmaceutical Co.,Ltd.
Contact:+86-576-87501888 / 87501988
Address:No.89 Zhongxing Road. Li'ao, Yuhuan, Zhejiang, China
Contact:+1-973-357-0577
Address:10 Taft Rd.
Doi:10.1016/j.catcom.2014.08.008
(2014)Doi:10.1007/BF01753072
(1975)Doi:10.1016/j.molcata.2004.09.051
(2005)Doi:10.1021/jo00186a038
(1984)Doi:10.1021/ja01575a003
(1957)Doi:10.1016/j.bmcl.2013.08.080
(2013)
