Rhodium(I) bis(aminophosphane) complexes as catalysts for asymmetric hydrogenation of activated ketones

Article abstract of DOI:10.1016/0957-4166(96)00011-0

The synthesis of new homochiral bis(aminophosphanes) (BAMP) 1-5 and their application in rhodium based asymmetric hydrogenation of dihydro-4,4-dimethyl-2,3-furandione 12 and N-benzylbenzoylformamide 14 are presented. Under mild conditions, the hydrogenations led to high enantiomeric excesses (up to 87% and 75% ere respectively for both substrates).