Chiral synthesis of (+)-aspicilin by using a furyl group as the masked γ-oxo-α,β-unsaturated carboxylic acid

Article abstract of DOI:10.1016/S0040-4039(97)10325-2

Synthesis of (+)-aspicilin is described. The decisive steps are the diastereoselective dihydroxylation of the key intermediate 2, the subsequent furan ring oxidation, and the chelation-controlled reduction of ketone 1.