Microbiological transformations. 25. Enantioselective Baeyer-Villiger oxidation as a tool for the synthesis of enantiopure bicyclic furofuran and pyrofuran chirons

Article abstract of DOI:10.1016/S0957-4166(00)80245-1

Several bicyclic [n.2.0] ketones were submitted to enzymatic Baeyer-Villiger oxidation and provided the corresponding regioisomeric lactones showing high enantiopurities. These products could be used as interesting chirons for the synthesis of various natural compounds. The absolute configurations of the obtained lactones were assigned using circular dichroism measurements.