Efficient method for the t-butyldimethylsilylation of alcohols with N,O-bis(t-butyldimethylsilyl)acetamide

Article abstract of DOI:10.1016/0040-4039(95)02232-5

The efficient t-butyldimethylsilylation of alcohols - including tertiary and sterically hindered secondary alcohols - can be achieved using N,O-bis(t-butyldimethylsilyl)acetamide (BTBSA) in the presence of catalytic amounts (0.01-0.05 equiv) of tetrabutyl