Facile Syntheses of AM-toxins and Analogs as Cyclic Depsipeptides by the Solid-phase Method

Article abstract of DOI:10.1271/bbb.62.1799

The cyclic depsipeptides, AM-toxins I and II and AM-toxin I analogs, were efficiently and rapidly prepared by the Fmoc-based solid-phase method for the synthesis of linear depsipeptides, with N-<(dimethylamino)-1H-1,2,3-triazolo<4,5-b>pyridin-1-ylmethylene>-N-methylmethanaminium hexafluorophosphate N-oxide (HATU) being used for their subsequent cyclization. - Keywords: Am-toxin; host-specific toxin; cyclic depsipeptide; solid-phase synthesis; HATU.