Synthesis of S-(3-Deazaadenosyl)-L-homocysteine

DOI: 10.1021/jm00144a028

Source and publish data:

Journal of Medicinal Chemistry p. 1514 - 1516 (1981)

Update date:2022-08-10

Topics:

Authors:

Montgomery, J. A.

Thomas, H. J.

Thorpe, M. C.

Chiang, P. K.

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Article abstract of DOI:10.1021/jm00144a028

A satisfactory procedure for the preparation of S-(3-deazaadenosyl)-L-homocysteine, a metabolite of 3-deazaadenosine, which is a potent inhibitor of S-adenosyl-L-homocysteine hydrolase with antiviral activity, is described.For the first time this compound is completely characterized and its optical purity established.

Full text of DOI:10.1021/jm00144a028

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