Polymer-bound carbonic anhydrides in N-acylation of 7-aminocephalosporanic acid.

Article abstract of DOI:10.1002/jps.2600670128

Aminocephalosporanic acid tert-butyl ester was reacted with polystyrene-bound mixed carbonic-carboxylic anhydrides to give the corresponding N-acylated derivatives. Clevage of the tert-butyl protecting group with trifluoroacetic acid gave the corresponding cephalosporanic acid.