New synthesis of leukotriene B3 methyl ester from bis(trimethylsilyl) unsaturated derivatives

DOI: 10.1016/S0040-4020(98)00146-X

Source and publish data:

Tetrahedron p. 4327 - 4336 (1998)

Update date:2022-08-11

Topics:

Authors:

Babudri, Francesco

Fiandanese, Vito

Hassan, Omar

Punzi, Angela

Naso, Francesco

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Article abstract of DOI:10.1016/S0040-4020(98)00146-X

A new synthesis of leukotriene B₃ methyl ester is reported starting from bis(trimethylsilyl) unsaturated derivatives as building blocks for the triene moiety of the leukotriene. The two stereogenic centers have been generated by enantioselective chemical reduction of two acetylenic ketones with both R- or S-Alpine Borane. The three conjugated double bonds system of the leukotriene has been assembled by Miyaura-Suzuki cross-coupling reaction.

Full text of DOI:10.1016/S0040-4020(98)00146-X

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