Synthesis of 2-Modified 1,3-Diacylglycerols

Article abstract of DOI:10.1016/0040-4020(94)01013-P

1,3-Diacylglycerols modified in 2-position were synthesized by combining enzymatic and chemical methods.The syntheses started from the regioisomerically pure 1,3-dilauroylglycerol or 1,3-dimyristoylglycerol obtained from glycerol and vinyl esters of carboxylic acids by means of lipase from Mucor mihei.The 2-hydroxyl group in the glycerol derivatives was subsequently substituted by phosphate as well as its disodium salt, by sulfate, phosphocholine, the benzyloxy, the succinimidyl or the amino group.