Synthesis of 6-Alkylpurine Derivatives by Nickel-comlex-catalyzed Coupling Reaction of 6-(Methylthio)purine Derivatives with Grignard Reagents

DOI: 10.1246/bcsj.58.664

Source and publish data:

Bulletin of the Chemical Society of Japan p. 664 - 666 (1985)

Update date:2022-08-10

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Authors:

Sugimura, Hideyuki

Takei, Hisashi

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Article abstract of DOI:10.1246/bcsj.58.664

6-(Methylthio)purine reacted with RMgX (R=C6H5, CH3(CH2)nCH2 (n=2 to 6), C6H5CH2CH2, (CH3)2C=CHCH2CH2) in the presence of 5 molpercent in refluxing THF for 8h to afford 6-aryl or 6-alkylpurines in 62-74percent yields.By applying

Full text of DOI:10.1246/bcsj.58.664

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