Activation and Orientation by Receptor-Substrate Binding. The Case of Acyl Transfer from O-Acetylhydroxylamine

Article abstract of DOI:10.1246/cl.1987.215

The strong binding ability of the receptor molecule 1 induces complexation of O-acetylhydroxylamine and of hydroxylamine in their protonated forms; as a result, subsequent reaction of bound CH3COONH3⁺ becomes fast and selective, giving only acetic acid with a rate enhancement by a factor of about 30.