Efficient and chemoselective access to 3-(chloromethyl)coumarins via direct cyclisation of unprotected Baylis-Hillman adducts

Article abstract of DOI:10.1055/s-2003-37655

Reaction of substituted 2-hydroxybenzaldehydes with t-butyl acrylate in the presence of DABCO has been shown to afford isolable Baylis-Hillman adducts, acid-catalysed cyclisation of which affords the corresponding 3-(chloromethyl)coumarins directly and in