Enantioselective Synthesis of erythro-β-Hydroxy-L-histidine, the Pivotal Amino Acid of Bleomycin-Fe(II)-O2 Complex

Article abstract of DOI:10.1246/cl.1988.83

erythro-β-Hydroxy-L-histidine, a novel amino acid constituent of bleomycin, has been synthesized enantioselectively via the reaction of (N-pyruvylideneglycyl-D-phenylalaninato)copper(II) with imidazole-4-carbaldehyde.