LITHIATION OF AN IMIDAZOLE NUCLEOSIDE AT THE C-5 POSITION. SYNTHESIS OF 3-DEAZAGUANOSINE FROM URIDINE

Article abstract of DOI:10.1246/cl.1985.589

3-Deazaguanosine, an antiviral nucleoside, was synthesized from uridine via lithiation of a C-2 protected imidazole nucleoside, which has been devised as a method for introducing various functionalities to the C-5 position.This furnished the first success