Organic Letters
Letter
Park, J. S.; Park, K.-H.; Hoffman, A. S.; Hahn, S. K.; Kim, K. ACS Nano
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In summary, a water-soluble C3-symmetrical rigid backbone
nanographene, which has application potential as a cell imaging
agent, was successfully synthesized and characterized by NMR,
MALDI-TOF MS, UV/vis, and fluorescence. Subsequently, a
multifunctional supramolecular platform was successfully
constructed by the supramolecular assembly of β-CD-modified
hexa-cata-hexabenzocoronene with the adamantyl-grafted HA.
As two typical examples of possible applications, it could
selectively image cancer cells over normal cells, and its
conjugate with the anticancer drug DOX displayed a higher
antitumor activity and a lower toxicity than the free DOX.
Considering the good water solubility and biocompatibility of
both β-CD-modified hexa-cata-hexabenzocoronene and ada-
mantyl-grafted HA, this achievement would not only provide
new access to associating nanographene with functional
substrates but also extend the possible application of nano-
graphene in many fields of pharmaceutical chemistry and
biological technology.
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2739. (b) Hillaireau, H.; Couvreur, P. Cell. Mol. Life Sci. 2009, 66,
2873−2896.
(14) Li, N.; Chen, Y.; Zhang, Y. M.; Yang, Y.; Su, Y.; Chen, J. T.; Liu,
Y. Sci. Rep. 2014, 4, 4164.
ASSOCIATED CONTENT
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* Supporting Information
The Supporting Information is available free of charge on the
Experimental details (PDF)
AUTHOR INFORMATION
Corresponding Author
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Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
We thank the NNSFC (21432004, 21272125, and 91527301)
for financial support.
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