Methylfuroquinolones: New furocoumarin isosters as potential photoreagents toward DNA

Article abstract of DOI:10.1002/jhet.5570260407

A number of methylfuro[3,2-g]quinolin-7(8H)-ones, which can be considered isosters of methylpsoralens, were synthesized. The synthesis was performed starting from the appropriate methyl quinolin-2-ones on which the methylfuran ring was condensed. The molar absorptivity at long wavelengths of these compounds is remarkably higher than that of the corresponding methylpsoralen isosters; this fact may lead to an improved photo-binding to the biological targets.