Tetrahedron p. 1141 - 1152 (1988)
Update date:2022-08-16
Topics:
Burger, Alain
Colobert, Francoise
Hetru, Charles
Luu, Bang
Two series of acetylenic derivatives of cholesterol were synthesized from stigmasterol and pregnenolone.These compounds carry an acetylenic function at C-22 and were devised with the aim to inhibit the C-22hydroxylation of ecdysone biosynthesis by a suicide-substrate mechanism.Two of these compounds (15a, 15f) inhibit the synthesis of ecdysone in follicular cells under in vitro conditions.The inhibition is selective of the C-22 hydroxylase system.
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(1981)
