Steroids p. 297 - 302 (1985)
Update date:2022-08-17
Topics:
Schoenemann, K. H.
Vliet, N. P. van
Zeelen, F. J.
13-Ethyl-18-norpregn-4-ene-3,20-dione (7) and 13-acetyl-18-norpregn-4-ene-3,20-dione (4) were synthesized and tested in the s.c.Clauberg assay.The potencies of these compounds (1x and 1/3 x progesterone, respectively) are compared with those reported for 13-vinyl- and 13-cyanomethyl-18-norpregn-4-ene-3,20-dione.A comparable activity (1/3 x progesterone) was found for 13-acetyl-18-norpregn-4-en-3-one (10) which lacks the 20-carbonyl group.
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