Synthesis of 9-(2-hydroxyethoxymethyl)guanine (acyclovir) from guanosine

Article abstract of DOI:10.1080/15257779508012376

A convenient synthesis of 9-(2-hydroxyethoxymethyl)guanine (acyclovir) from guanosine by chemical transpurination was developed. The isomerization of the 7-isomer to the desired 9-isomer and the purification of the 9- isomer was achieved simply by concentration, heating and further crystallization.

Full text of DOI:10.1080/15257779508012376

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Nucleosides and Nucleotides
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Synthesis of 9-(2-
Hydroxyethoxymethyl)guanine
(Acyclovir) from Guanosine
Hiroshi Shiragami a , Yoshihito Koguchi a , Yasuhiro Tanaka a , Satoshi
Takamatsu a , Yumiko Uchida a , Takashi Ineyama a & Kunisuke Izawa
a
a Central Research Laboratories, Ajinomoto Co., Inc, 1-1 Suzuki-cho,
Kawasaki-ku, Kawasaki, 210, Japan
Version of record first published: 16 Feb 2007.
To cite this article: Hiroshi Shiragami , Yoshihito Koguchi , Yasuhiro Tanaka , Satoshi
Takamatsu , Yumiko Uchida , Takashi Ineyama & Kunisuke Izawa (1995): Synthesis of 9-(2-
Hydroxyethoxymethyl)guanine (Acyclovir) from Guanosine, Nucleosides and Nucleotides, 14:3-5,
337-340
To link to this article: http://dx.doi.org/10.1080/15257779508012376
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