Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-ray Structural Studies

DOI: 10.1002/cmdc.201900508

Source and publish data:

ChemMedChem p. 1863 - 1872 (2019)

Update date:2022-08-11

Topics:

Authors:

Ghosh, Arun K.

Xia, Zilei

Kovela, Satish

Robinson, William L.

Johnson, Megan E.

Kneller, Daniel W.

Wang, Yuan-Fang

Aoki, Manabu

Takamatsu, Yuki

Weber, Irene T.

Mitsuya, Hiroaki

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Article abstract of DOI:10.1002/cmdc.201900508

We report the synthesis and biological evaluation of phenylcarboxylic acid and phenylboronic acid containing HIV-1 protease inhibitors and their functional effect on enzyme inhibition and antiviral activity in MT-2 cell lines. Inhibitors bearing bis-THF l

Full text of DOI:10.1002/cmdc.201900508

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