Preparations of melatonin and 1-hydroxymelatonin, and its novel nucleophilic dimerization to (±)-3a,3a'-bispyrrolo[2,3-b]indoles

DOI: 10.3987/COM-99-8542

Source and publish data:

Heterocycles p. 1237 - 1242 (1999)

Update date:2022-08-11

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Authors:

Somei, Masanori

Oshikiri, Naoki

Hasegawa, Masakazu

Yamada, Fumio

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Article abstract of DOI:10.3987/COM-99-8542

A unique synthetic method for melatonin was established through biologically promising synthetic intermediates. 1-Hydroxymelatonin was prepared as crystals for the first time. It reacted with 85% formic acid to give (±)-3a,3a'-bispyrrolo[2,3-b]indole compound, whose structure was unequivocally determined by X-Ray crystallographic analysis.

Full text of DOI:10.3987/COM-99-8542

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