Chemical and Pharmaceutical Bulletin p. 1046 - 1051 (1997)
Update date:2022-08-10
Topics:
Kanazawa, Tsutomu
Ohkawa, Yuki
Kuda, Takashi
Minobe, Yasushi
Tani, Tadato
Nishizawa, Makoto
New γ-pyrones, 9'-oxopodopyrone (3) and 8-methyl-9'-oxopodopyrone (4) were isolated from the leaves of Gonystylus keithii, along with known γ- pyrones, 10'-oxopodopyrone (1) and 8-methyl-10'-oxopodopyrone (2). These γ- pyrones markedly inhibited the bovine parathyroid hormone (PTH)-induced Ca release from neonatal mouse calvaria in vitro. It is the first time that γ- pyrones showed inhibitory effects on bone resorption, and these compounds may be seed compounds of new drugs for osteoporosis.
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