Merrifield MicroTube(TM) reactors for solid phase synthesis

Article abstract of DOI:10.1016/S0040-4039(98)01963-7

Polystyrene grafted polypropylene MicroTube(TM) reactors (length x OD, 25 x 5 mm) have been functionalized with chloromethyl groups (Merrifield- type) using chloromethyl methyl ether and Lewis acid catalysts. A potentiometric method using a chloride ion selective electrode has been developed to measure the loading of the Merrifield MicroTube(TM) reactors. A typical loading of 25-35 μmol/tube for Merrifield MicroTube(TM) reactors has been achieved. Several reactions performed on Merrifield MicroTube(TM) reactors demonstrated that they are excellent supports for solid phase synthesis. As a result of the ease with which radiofrequency memory tags can be associated with and separated from the supports, these MicroTube(TM) reactors can facilitate the synthesis of combinatorial libraries.