An improved method for the preparation of 3,5-difluorosalicylaldehyde and 3,5-difluorosalicylic acid

Article abstract of DOI:10.1080/00397919608004595

An improved method for the synthesis of 3,5-difluorosalicylic acid (3b) and 3,5-difluorosalicylaldehyde (3a) is described. 2,4-Difluorophenol (4) undergoes a formylation reaction to afford aldehyde 3a which is oxidized to the desired acid 3b. This method

Full text of DOI:10.1080/00397919608004595

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Synthetic Communications: An
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An Improved Method for
the Preparation OF 3,5-
Difluorosalicylaldehyde and
3
,5-Difluorosalicylic Acid
a
Michele A. Weidner-Wells & Stephanie A. Fraga-
a
Spano
a
Drug Discovery, The R.W. Johnson Pharmaceutical
Research Institute, 1000 Route 202, Raritan, N.J.,
08869
Version of record first published: 21 Aug 2006.
To cite this article: Michele A. Weidner-Wells & Stephanie A. Fraga-Spano (1996):
An Improved Method for the Preparation OF 3,5-Difluorosalicylaldehyde and 3,5-
Difluorosalicylic Acid , Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 26:14, 2775-2781
To link to this article: http://dx.doi.org/10.1080/00397919608004595
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