Direct synthesis of keto nitroaliphatics via retro-Henry reaction of cyclic 2-nitroalcohols by anhydrous copper sulfate adsorbed on silica gel. A short synthesis of (±)-phoracantholide I

Article abstract of DOI:10.1055/s-1996-4318

It has been observed that anhydrous CuSO₄ adsorbed on silica gel effects the C-C bond cleavage between the hydroxy group and the nitro group of 2-nitroalcohols. In the case of 2-nitrocyclohexanols, the products are RCO(CH₂)₄