Pseudoesters and derivatives xxxvi. reactions of enolates of 5-ethylthiofuran-2(5h)-ones with aromatic aldehydes: A synthesis of losigamone

Article abstract of DOI:10.3987/com-95-7258

The furanones (3a) and (3b), key intermediates in our approach to losigamone (1₂), have been prepared by reaction of 2-chlorobenzaldehyde with the enolates (2A) and (2B) of the corresponding tetronic acid derivatives (2a) and (2b). The reductiv