An organometallic route to 2'-hydroxy-6'-methoxy-acetophenone

Article abstract of DOI:10.1080/00397919508010801

2'-Hydroxy-6'-methoxyacetophenone was obtained in 66% yield from 3-methoxyphenol. In the key step, 3-methoxyphenol protected by means of ethylvinyl ether was selectively metallated at the 2-position with butyllithium. Addition of ZnCl₂ to the aryllithium gave the corresponding organozinc compound, which readily reacted on acetyl chloride under palladium catalysis.

Full text of DOI:10.1080/00397919508010801

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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An Organometallic Route
to 2′-Hydroxy-6′-methoxy-
acetophenone
Zoia Mincheva a , Jivko Velkov b , Gérade Boireau c ,
Jean Barry c & Claude Fugier d
a Department of Chemistry , University of Sofia , 1
James Bourchier avenue, 1126, Sofia, Bulgaria
b SW University of Blagoevgrad, Department of
Chemistry , Blagoevgrad, Bulgaria
c Institut de Chimie Moléculaire d'Orsay, Laboratoire
de Chimie Organométallique, Université de Paris-
Sud, Centre d'Orsay , 91405, Orsay Cedex, France
d ORIL, 13, rue Auguste Desgenétais , B.P. 17, 76210,
Bolbec
Published online: 23 Sep 2006.
To cite this article: Zoia Mincheva , Jivko Velkov , Gérade Boireau , Jean
Barry & Claude Fugier (1995) An Organometallic Route to 2′-Hydroxy-6′-
methoxy-acetophenone, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 25:2, 149-155, DOI:
10.1080/00397919508010801
To link to this article: http://dx.doi.org/10.1080/00397919508010801
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