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4 | CONCLUSION
In conclusion, we have successfully resolved 6,12‐
diphenylbenzo[b,f][1,5]diazocine 3 by chiral supercritical
fluid chromatography for the first time. The chirality of 3 is
induced by the nonplanarity of the diaza‐eight‐membered
ring and the fixed directionality within it. The absolute con-
figurations of the two optically pure enantiomers were
assigned and determined by analogous CIP rules and crystal
X‐ray diffraction, respectively. The very high conformational
inversion barrier makes it possible to retain the chirality
completely even after prolonged heating at 200 °C in the melt
state. Their high optical rotation and CD spectrum are well
explained by electronic helix theory.
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of chirality in an atropisomerically enriched two‐axis system.
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ACKNOWLEDGEMENTS
This work is supported by NSFC (Nos. 21572026 and
21002009), the Natural Science Foundation of Jiangsu Col-
leges and Universities (14KJA150002), Advanced Catalysis
and Green Manufacturing Collaborative Innovation Center,
Changzhou University (ACGM2016‐06‐05), and the Priority
Academic Program Development of Jiangsu Higher Educa-
tion Institutions.
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total synthesis of axially chiral biaryl natural products. Chem Rev.
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