Three-dimensional quantitative structure-activity relationships of 5-HT receptor binding data for tetrahydropyridinylindole derivatives: A comparison of the Hansch and CoMFA methods

DOI: 10.1021/jm00077a003

Source and publish data:

Journal of Medicinal Chemistry p. 4006 - 4014 (1993)

Update date:2022-08-17

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Authors:

Agarwal Agarwal

Pearson Pearson

Taylor Taylor

Dahlgren

Herslof Herslof

Yang Yang

Lambert Lambert

Nelson Nelson

Regan Regan

Martin Martin

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Article abstract of DOI:10.1021/jm00077a003

A series of new derivatives of 3-(1,2,5,6-tetrahydropyridin-4-yl)indole (4-THPI) has been synthesized, and their dissociation constants at the 5- HT(1A) and 5-HT₂ serotonin (5-HT) receptor subtypes have been determined. The new data were combin

Full text of DOI:10.1021/jm00077a003

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Product name:5-methoxy-3-(1-propyl-1,2,3,6-tetrahydropyridin- 4-yl)-1H-indole

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