Asymmetric Grignard cross-coupling reaction between (E)-β-bromostyrene and 1-phenylethylmagnesium chloride

Article abstract of DOI:10.1016/0022-328X(87)85186-0

Trans-2,3-bis-(diphenylphosphinomethyl)-norbornene-(5), trans-2,3-bis-(diphenylphosphinomethyl)-7-oxanorbornane, and (-)-/2((S)-1-dimethylaminoethyl)phenyl/-diphenylphosphine have been used as ligands for the nickel and palladium catalyzed asymmetric Grignard cross-coupling reaction giving the coupling product (E)-1,3-diphenyl-1-butene.Chemical yields from 60 to 95percent and optical yields up to 40percent were obtained, depending on the types of ligand coordinated.